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KMID : 0616120160470040333
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Korean Journal of Pharmacognosy
2016 Volume.47 No. 4 p.333 ~ p.342
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The Anti-osteoporosis Effects of Cassia tora L. Seed Ethanol Extract in Ovariectomixed Rats
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Lee Mu-Jin
An Byeong-Kwan
Jung Ho-Kyung
Lee Ki-Ho
Kim A-Hyeon
Lee Hyun-Joo
Jang Ji-Hun
Sim Mi-Ok
Kim Tae-Muk
Kim Min-Suk
Seong Tae-Kyoung
Woo Kyeong-Wan
Cho Jung-Hee
Kim Jong-Choon
Cho Hyun-Woo
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Abstract
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In our study, osteoporosis was induced by ovariectomized in female rats, and the prevention and treatment efficacy of the climacteric disease the postmenopausal type I pattern was examined by using the experimental substance Cassia tora (CT) ethanol extracts. Female rats were either sham-operated (sham; n=5) or surgically ovariectomized (OVX; five animals per group) and then administered to OVX control, raloxifene hydrochloride (RLX) 1 mg/kg/day, or CT (20 and 200 mg/kg/day) for 12 weeks. Serum osteocalcin and creatinine concentration were significantly lower in the CT 200 mg/kg/day group com-pared with the OVX control group. Serum progesterone concentration was significantly higher in the CT 200 mg/kg/day group compared with the OVX control group. Reduction grade of the trabecular bone decreased in the RLX 1 and CT 200 mg/kg/ day group compared with that of the OVX control group. In conclusion, CT 200 mg/kg/day may have inhibitory effects on oste-oporosis in OVX rats.
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KEYWORD
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Cassia tora L. Ovariectomized, Osteocalcin, Progesterone, Creatinine
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